A GLP-1 is a subcutaneous injection — into the fat just under the skin. The labels list three main areas: the abdomen, thigh and upper arm. Here is where and how, in plain English. This is educational, not medical advice; the label and your clinician are the authority.
| Site | Where exactly |
|---|---|
| Abdomen (belly) | The soft area around the stomach, staying about two inches away from the navel. |
| Front of the thigh | The fleshy top/front of the upper thigh. |
| Back of the upper arm | The fatty area at the back of the upper arm (often easier if someone helps). |
Using the same exact spot over and over can cause lumps or firm areas (lipohypertrophy) that change how the medicine absorbs. Rotating — moving to a fresh spot at least a finger-width from the last one — keeps tissue healthy and absorption steady. Some people keep to one general area for a while, just moving around within it.
Whether you use a pre-filled pen or draw from a vial, the sites are the same. For the general steps, see how to inject a GLP-1 at home and how to give a subcutaneous injection.
Subcutaneously in one of three areas listed on the labels: the abdomen (about two inches from the navel), the front of the thigh, or the back of the upper arm.
Stay about two inches away from the navel when using the abdomen, and avoid tender, bruised or hardened skin.
It is better to rotate. Repeatedly using one exact spot can cause lumps that change absorption. Move to a fresh spot at least a finger-width away.
No — the dose is the same. Rotating sites is about keeping tissue healthy and absorption consistent, not changing the amount.
All three are approved. Pick what is comfortable and easy to reach cleanly; many people find the abdomen simplest. Rotate among the areas over time.